Holy Cross Lutheran Church was formed in 1965 as a mission start on the east side of Beatrice with the encouragement of members from the larger American Lutheran Church congregation, St. John Lutheran, Beatrice. Several of the charter members remain active in the congregation today. The first worship service on October 10, 1965 was at the Lincoln School, located just down 19th Street. Holy Cross was officially received into the ALC on January 19, 1966. The church building was dedicated at the current location later that year. In 1988, Holy Cross became part of the newly formed Evangelical Lutheran Church in America. In 1998-1999, a partnership with Trinity Lutheran Church, Beatrice was formed with shared pastoral leadership until 2004.